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Clinical Applications


2.10 Circadian Rhythm Influences on Medical Conditions, and Risk Factors

While our literature survey has emphasized circadian factors that affect psychological and sleep disturbances, and non-drug treatment approaches that normalize the daily cycle, there...

2.01 Seasonal Affective Disorder and Light Therapy

Light therapy for winter depression (seasonal affective disorder) was first developed and explored about 35 years ago at the US National Institute of Mental...

2.07 Prospects for New Applications of Light Therapy

We are far from knowing the limits of light therapy, or the involvement of circadian timing in mental and physical illness. New exploratory applications...

2.09 Chronotype, Circadian Clock Phase, and Period

Night owl or lark or in-between: everyone operates on a circadian cycle referenced to day and night outdoors.  There are two main ways to...

2.02 Later Demonstrations of Light Therapy for Psychiatric Disorders

Given the success and rapid spread of light therapy for SAD, clinical researchers immediately wondered how far the simple technology could be applied.  Multiple...

2.03 Circadian Rhythm Sleep Disorders and Their Treatment

No one will be surprised that our sleep-wake cycle is closely related to the circadian timing system.  This first became obvious in time-isolation studies...

2.05 Circadian Analysis of Jet Lag, and Treatment Approaches

When we take a flight across time zones, our circadian timing system has no knowledge of the shift to a new light-dark cycle, so...

2.06 Circadian Analysis of Shift Work Disorder, and Treatment Approaches

Shift workers are required to be awake and alert, often at times when the circadian clock is in its incompatible nighttime mode.  The ensuing...

2.08 Chronotherapeutics: Light and Wake Therapy

A remarkable observation in the 1970’s—inspired by a depressed bipolar patient who stayed awake bike riding all night—was the immediate relief of deep depression...

2.04 Circadian Properties of Melatonin and Its Relationship to Sleep

The hormone melatonin, produced by the pineal gland, is a sleep facilitator with circadian action. In the normal case, the inner clock in the...